Cisplatin is a chemotherapy drug used to treat a number of cancers including mesothelioma. It was first approved in America by the Food and Drug Administration in 1978 and is still being used as treatment today. The medication is given alongside Alimta and takes approximately 2 hours to administer intravenously. The drug is used to target and kill cancer cells. Patients are likely to receive B12 shots throughout the treatment of this drug.
In trials carried out in America in unique cases where high doses of the drug were administered along with doxorubicin it was effective in sending mesothelioma into partial remission. Where more conventional doses have been administered positive response rates were also seen with 67% in 6 patients, 42% in 19 patients and 25% in 24 patients. In a study by Dr Sugarbaker combined extra pleural pneumonectomy with radiation to the hemi thorax and chemotherapy with Cisplatin, doxorubicin and cyclophosphamide in 120 patients. The overall survival was 45% at 2 years and 22% at 5 years.
The side effects of this drug include hair loss, fatigue, vomiting and kidney toxicity.